YB1 (phospho-Ser102) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES12267-50, ES12267-100

Citations, Manuals and MSDS Available upon request.

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate gene

Alternate Name: Tryptase alpha/beta-1 (Tryptase-1) (EC 3.4.21.59) (Tryptase I) (Tryptase alpha-1)

Source: Rabbit

Applications: WB

Dilution: WB 1:1000-2000

Reactivity: Human; Mouse

Immunogen: Synthesized phosho peptide around human YB1 (Ser102)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 30kD

Human Gene ID: 7177

Human SWISS Prot NO: Q15661

Subcellular Location: Secreted. Released from the secretory granules upon mast cell activation.

Research Use Only