"I will be at the South Street Seaport everyday at mid-day, when the sun is highest in the sky. If you are out there... if anyone is out there... I can provide food, I can provide shelter, I can provide security."

A deadly virus, initially intended to cure cancer, goes out of control, wiping out a vast majority of humanity. Robert Neville, a US Army virologist, finds himself the sole surviving human in New York City, except for the mutated, nocturnal infected.  These are monstrous creatures who emerge at night, driven by a bloodlust and a relentless desire to hunt.  He works tirelessly to find a cure for the virus, sending out daily radio messages in a futile attempt to find other survivors.