LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM).

Product information

CAS Number: 1638667-79-4

Molecular Weight: 450.40

Formula: C24H29Cl2NO3

Chemical Name: 2-(2,6-dichlorophenyl)-1-[(1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl]ethan-1-one

Smiles: C[C@H]1C2C=CC=C(CCC(C)(C)O)C=2C[C@H](CO)N1C(=O)CC1C(Cl)=CC=CC=1Cl

InChiKey: XHCSBQBBGNQINS-DOTOQJQBSA-N

InChi: InChI=1S/C24H29Cl2NO3/c1-15-18-7-4-6-16(10-11-24(2,3)30)19(18)12-17(14-28)27(15)23(29)13-20-21(25)8-5-9-22(20)26/h4-9,15,17,28,30H,10-14H2,1-3H3/t15-,17+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 110 mg/mL (244.23 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

In HEK293 cells transiently expressing human, dog, rhesus monkey, and mouse D1 receptors, the EC50s of LY3154207 are 2.3 nM, 2.0 nM, 2.5 nM, and 62.1 nM, respectively.

Products are for research use only. Not for human use.